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208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

208722
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₂H₂₆N₂O₄ 88191-84-8

Products

Número de referenciaEmbalaje Cant./Env.
208722-25MG Ampolla de plást. 25 mg
Description
OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
Catalogue Number208722
Brand Family Calbiochem®
SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
References
ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
Product Information
CAS number88191-84-8
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₂H₂₆N₂O₄
Chemical formulaC₂₂H₂₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Applications
ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target IC<sub>50</sub>8 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Val-Phe-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
208722

Referencias bibliográficas

Visión general referencias
Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure

Citas

Título
  • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
  • Dong, Y., et al. 2006. FASEB Journal in press,.
  • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-May-2008 RFH
    SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
    DescriptionA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
    FormWhite lyophilized solid
    CAS number88191-84-8
    Chemical formulaC₂₂H₂₆N₂O₄
    Peptide SequenceZ-Val-Phe-CHO
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (20 mg/ml). Use only anhydrous DMSO.
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
    Rami, A., et al. 1997. Neurosci. Res. 27, 93.
    Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
    Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
    Chard, P.S., et al. 1995. Neuroscience 65, 1099.
    Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
    Citation
  • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
  • Dong, Y., et al. 2006. FASEB Journal in press,.
  • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.