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215902 Carbonic Anhydrase IX Inhibitor III, Methazolamide - CAS 554-57-4 - Calbiochem

215902
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₅H₈N₄O₃S₂ 554-57-4

Products

Número de referenciaEmbalaje Cant./Env.
215902-50MG Frasco de vidrio 50 mg
Description
OverviewA cell-permeable thiadiazolylsulfonamide derivative that acts as a carbonic anhydrase (CA) inhibitor (Ki = 20 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. May induce death in hypoxic tumor cells by inhibiting tumor-associated CAIX in maintaining an acidic tumor microenvironment, and blocking CAIX-dependent resistance to chemotherapy in these tumors. Shown to enhance insulin sensitivity and reduce HbA1c levels in diabetic rodent models in a dose-dependent manner. Shown to reduce oxygen and glucose-deprived cell death in primary cerebrocortical neurons by diminishing the release of cytochrome c and dissipating the mitochondrial membrane potential gradient.
Catalogue Number215902
Brand Family Calbiochem®
SynonymsN-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, Carbonic Anhydrase Inhibitor, Methazolamide, CAIX Inhibitor III
References
ReferencesMaren, T., et al. 1977. Invest Ophthalmol Vis Sci. 16, 730.
Chegwidden, W. R. and Spencer, I. M. 1995. Inflammopharmacology. 3, 231.
Wang, X., et al. 2009. Stroke. 40, 1877.
Konstantopoulos, N., et al. 2012. Diabetes.
Product Information
CAS number554-57-4
FormWhite powder
Hill FormulaC₅H₈N₄O₃S₂
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetcarbonic anhydrase
Primary Target K<sub>i</sub>20 nM
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Carbonic Anhydrase IX Inhibitor III, Methazolamide - CAS 554-57-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Carbonic Anhydrase IX Inhibitor III, Methazolamide - CAS 554-57-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
215902

Referencias bibliográficas

Visión general referencias
Maren, T., et al. 1977. Invest Ophthalmol Vis Sci. 16, 730.
Chegwidden, W. R. and Spencer, I. M. 1995. Inflammopharmacology. 3, 231.
Wang, X., et al. 2009. Stroke. 40, 1877.
Konstantopoulos, N., et al. 2012. Diabetes.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2012 JSW
SynonymsN-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, Carbonic Anhydrase Inhibitor, Methazolamide, CAIX Inhibitor III
DescriptionA cell-permeable thiadiazolylsulfonamide derivative that acts as a carbonic anhydrase (CA) inhibitor (Ki = 20 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. May induce death in hypoxic tumor cells by inhibiting tumor-associated CAIX in maintaining an acidic tumor microenvironment, and blocking CAIX-dependent resistance to chemotherapy in these tumors. Shown to enhance insulin sensitivity and reduce HbA1c levels in diabetic rodent models in a dose-dependent manner. Shown to reduce oxygen and glucose-deprived cell death in primary cerebrocortical neurons by diminishing the release of cytochrome c and dissipating the mitochondrial membrane potential gradient.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number554-57-4
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMaren, T., et al. 1977. Invest Ophthalmol Vis Sci. 16, 730.
Chegwidden, W. R. and Spencer, I. M. 1995. Inflammopharmacology. 3, 231.
Wang, X., et al. 2009. Stroke. 40, 1877.
Konstantopoulos, N., et al. 2012. Diabetes.