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264155 Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

264155
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₃₀H₄₁FN₄O₁₂ 210344-95-9

Products

Número de referenciaEmbalaje Cant./Env.
264155-1MG Ampolla de plást. 1 mg
264155-250UG Ampolla de plást. 250 μg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Catalogue Number264155
Brand Family Calbiochem®
SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
References
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Product Information
CAS number210344-95-9
ATP CompetitiveN
FormWhite to slightly brown solid
Hill FormulaC₃₀H₄₁FN₄O₁₂
Chemical formulaC₃₀H₄₁FN₄O₁₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
Biological Information
Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Purity≥90% by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
264155

Referencias bibliográficas

Visión general referencias
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure

Citas

Título
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision31-March-2011 RFH
    SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
    DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
    FormWhite to slightly brown solid
    CAS number210344-95-9
    Chemical formulaC₃₀H₄₁FN₄O₁₂
    Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
    Structure formulaStructure formula
    Purity≥90% by TLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Protect from moisture
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
    Nicholson, D.W. 1996. Nature Biotech. 14, 297.
    Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
    Nicholson, D.W., et al. 1995. Nature 376, 37.
    Citation
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.