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264158 Caspase Modulator II, 1541B - Calbiochem

264158
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₃H₁₅N₃O₄

Products

Número de referenciaEmbalaje Cant./Env.
264158-10MG 10 mg
Description
OverviewA cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662) that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
Catalogue Number264158
Brand Family Calbiochem®
SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
References
ReferencesWolan, D.W., et al. 2009. Science 326, 853.
Product Information
FormPale yellow solid
Hill FormulaC₂₃H₁₅N₃O₄
Chemical formulaC₂₃H₁₅N₃O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Caspase Modulator II, 1541B - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Caspase Modulator II, 1541B - Calbiochem Certificados de análisis

CargoNúmero de lote
264158

Referencias bibliográficas

Visión general referencias
Wolan, D.W., et al. 2009. Science 326, 853.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2011 RFH
SynonymsProcaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI
DescriptionA cell-permeable, of 8-Hydroxy 1541 (Cat. No. 529662) analog that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective as simultaneous activations of caspase-3/-6 in cell death induction of the cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₁₅N₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (1.8 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWolan, D.W., et al. 2009. Science 326, 853.