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219433 Cathepsin L Inhibitor IV - Calbiochem

219433
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₇H₂₉N₃O₄S

Products

Número de referenciaEmbalaje Cant./Env.
219433-1MG Ampolla de plást. 1 mg
Description
OverviewA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
Catalogue Number219433
Brand Family Calbiochem®
Synonyms1-Naphthalenesulfonyl-IW-CHO
References
ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
Product Information
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₇H₂₉N₃O₄S
Chemical formulaC₂₇H₂₉N₃O₄S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetcathepsin L
Primary Target IC<sub>50</sub>1.9 nM against Cathepsin L
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cathepsin L Inhibitor IV - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cathepsin L Inhibitor IV - Calbiochem Certificados de análisis

CargoNúmero de lote
219433

Referencias bibliográficas

Visión general referencias
Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

Citas

Título
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-January-2019 JSW
    Synonyms1-Naphthalenesulfonyl-IW-CHO
    DescriptionA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Inhibits the release of Ca2+ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
    FormWhite to off-white solid
    Chemical formulaC₂₇H₂₉N₃O₄S
    Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
    Citation
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.