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238806 Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem

238806
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₄H₁₂N₆O₂S 507487-89-0

Products

Número de referenciaEmbalaje Cant./Env.
238806-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
Catalogue Number238806
Brand Family Calbiochem®
Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
References
ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
Wang, S., et al. 2004. J. Med. Chem. 47, 1662.
Product Information
CAS number507487-89-0
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₄H₁₂N₆O₂S
Chemical formulaC₁₄H₁₂N₆O₂S
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCdk2/E and Cdk9/T1
Primary Target K<sub>i</sub>2 nM and 4 nM against Cdk2/E and Cdk9/T1, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cdk2/9 Inhibitor - CAS 507487-89-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
238806

Referencias bibliográficas

Visión general referencias
Kontopidis, G., et al. 2006. Chem. Biol. 13, 201.
Wang, S., et al. 2004. J. Med. Chem. 47, 1662.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
Synonyms(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine, Cdk7 Inhibitor III
DescriptionA cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number507487-89-0
Chemical formulaC₁₄H₁₂N₆O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKontopidis, G., et al. 2006. Chem. Biol. 13, 201.
Wang, S., et al. 2004. J. Med. Chem. 47, 1662.