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238803 Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

238803
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₀H₂₈N₆O₃ 199986-75-9

Products

Número de referenciaEmbalaje Cant./Env.
238803-1MG Ampolla de plást. 1 mg
238803-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
Catalogue Number238803
Brand Family Calbiochem®
Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
References
ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
Product Information
CAS number199986-75-9
ATP CompetitiveY
DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
FormWhite solid
Hill FormulaC₂₀H₂₈N₆O₃
Chemical formulaC₂₀H₂₈N₆O₃
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCdk2/A, Cdk2/E
Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
238803

Referencias bibliográficas

Visión general referencias
Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-November-2008 RFH
Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number199986-75-9
Chemical formulaC₂₀H₂₈N₆O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.