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234109 Colcemid - CAS 477-30-5 - Calbiochem

234109
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₁H₂₅NO₅ 477-30-5

Products

Número de referenciaEmbalaje Cant./Env.
234109-5MG Tambor de alum 5 mg
Description
OverviewCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Catalogue Number234109
Brand Family Calbiochem®
SynonymsDemecolcine
References
ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.
Product Information
CAS number477-30-5
ATP CompetitiveN
FormCrystalline powder
Hill FormulaC₂₁H₂₅NO₅
Chemical formulaC₂₁H₂₅NO₅
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetDepolymerizes microtubules and limits microtubule formation.
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGH0800000
Safety Information
R PhraseR: 25-63

Toxic if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Colcemid - CAS 477-30-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Colcemid - CAS 477-30-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
234109

Referencias bibliográficas

Visión general referencias
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsDemecolcine
DescriptionCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
FormCrystalline powder
CAS number477-30-5
RTECSGH0800000
Chemical formulaC₂₁H₂₅NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol and chloroform (10 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 2887
ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.