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239764 Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₅H₂₃NO₄ 66-81-9

Products

Número de referenciaEmbalaje Cant./Env.
239764-100MG Frasco de vidrio 100 mg
239764-1GM Tambor de alum 1 gm
Description
OverviewAntifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
Catalogue Number239764
Brand Family Calbiochem®
References
ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Product Information
CAS number66-81-9
FormWhite solid
Hill FormulaC₁₅H₂₃NO₄
Chemical formulaC₁₅H₂₃NO₄
Structure formula ImageStructure formula Image
Applications
ApplicationCycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.
Biological Information
Primary TargethFKBP12
Primary Target K<sub>i</sub>3.4 µM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMA4375000
Safety Information
R PhraseR: 28-40-51/53-61

Very toxic if swallowed.
Limited evidence of a carcinogenic effect.
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
May cause harm to the unborn child.
S PhraseS: 45-53-61

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
239764

Referencias bibliográficas

Visión general referencias
Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
Waring, P. 1990. J. Biol. Chem. 265, 14476.

Folleto

Cargo
Tools and Tips for Analyzing Apoptosis

Citas

Título
  • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision29-April-2008 RFH
    DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
    FormWhite solid
    CAS number66-81-9
    RTECSMA4375000
    Chemical formulaC₁₅H₂₃NO₄
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityChloroform, Ethanol, and Methanol
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
    Toxicity Highly Toxic & Carcinogenic / Teratogenic
    Merck USA index14, 2728
    ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
    Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
    Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
    Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
    Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
    Waring, P. 1990. J. Biol. Chem. 265, 14476.
    Citation
  • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.