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239803 Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

239803
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₇H₄₁NO₂ 4449-51-8

Products

Número de referenciaEmbalaje Cant./Env.
239803-1MG Frasco de vidrio 1 mg
239803-5MG Frasco de vidrio 5 mg
Description
OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806).
Catalogue Number239803
Brand Family Calbiochem®
SynonymsShh Signaling Antagonist I
References
ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Product Information
CAS number4449-51-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₇H₄₁NO₂
Chemical formulaC₂₇H₄₁NO₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetHh signaling in Shh-light2 assay
Primary Target IC<sub>50</sub>20 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGY0750000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
239803

Referencias bibliográficas

Visión general referencias
Berman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-October-2007 JSW
SynonymsShh Signaling Antagonist I
DescriptionA cell-permeable, steroidal alkaloid and cholesterol mimic that displays both teratogenic and anti-tumor properties. Disrupts cholesterol biosynthesis and specifically antagonizes shh (Sonic Hedgehog) signaling through direct interaction with Smo (smoothened), a protein that is related to G-protein-coupled receptors. Useful for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number4449-51-8
RTECSGY0750000
Chemical formulaC₂₇H₄₁NO₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (4 mg/ml), Ethanol (5 mg/ml), or DMF (10 mg/ml). Ethanol stock solutions may require warming to achieve complete solubilization.
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.