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376650 D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

376650
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₄H₄₇NO₃ 124753-97-5

Products

Número de referenciaEmbalaje Cant./Env.
376650-5MG Ampolla de plást. 5 mg
Description
OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Catalogue Number376650
Brand Family Calbiochem®
SynonymsC₆ Ceramide
References
ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
Product Information
CAS number124753-97-5
ATP CompetitiveN
FormWhite waxy solid
Hill FormulaC₂₄H₄₇NO₃
Chemical formulaC₂₄H₄₇NO₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetMAP kinase, protein phosphatase 2A (PP2A)
Primary Target IC<sub>50</sub>Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
376650

Referencias bibliográficas

Visión general referencias
Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

Folleto

Cargo
Bioactive Lipids Technical Bulletin
Caspases and other Apoptosis Related Tools Brochure
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-September-2019 JSW
SynonymsC₆ Ceramide
DescriptionBiologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.
FormWhite waxy solid
CAS number124753-97-5
Chemical formulaC₂₄H₄₇NO₃
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO or Ethanol (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Irritant
ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.