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317700 Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

317700
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₀H₂₂N₄ • HCl

Products

Número de referenciaEmbalaje Cant./Env.
317700-10MG Frasco de vidrio 10 mg
Description
OverviewA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Catalogue Number317700
Brand Family Calbiochem®
Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
References
ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
Product Information
FormYellow powder
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₂₀H₂₂N₄ • HCl
Chemical formulaC₂₀H₂₂N₄ • HCl
Structure formula ImageStructure formula Image
Applications
ApplicationDkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem Certificados de análisis

CargoNúmero de lote
317700

Referencias bibliográficas

Visión general referencias
Pelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2016 JSW
Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
DescriptionA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
FormYellow powder
FormulationSupplied as a hydrochloride salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₂N₄ • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.