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324673 EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

324673
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₃H₂₁N₃O₃ 179248-61-4

Products

Número de referenciaEmbalaje Cant./Env.
324673-1MG Ampolla de plást. 1 mg
Description
OverviewA cell-permeable 4-anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM and 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 = ~ 1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
Catalogue Number324673
Brand Family Calbiochem®
Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
References
ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
Product Information
CAS number179248-61-4
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₃H₂₁N₃O₃
Chemical formulaC₂₃H₂₁N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>20 nM and 79 nM, against EGFR and c-erbB2, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
324673

Referencias bibliográficas

Visión general referencias
Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of EGFR (IC50 = 20 nM) and c-erbB2 (IC50 = 79 nM), members of the type I growth factor receptor family implicated in the development and progression of various forms of cancer, including breast and small lung cell carcinoma. Shown to effectively inhibit the proliferation (IC50 ~1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number179248-61-4
Chemical formulaC₂₃H₂₁N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml) or Methanol (1 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.