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324833 EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem

324833
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₆H₁₀Cl₃FN₄O 733009-42-2

Products

Número de referenciaEmbalaje Cant./Env.
324833-5MG Frasco de vidrio 5 mg
Description
OverviewA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
Catalogue Number324833
Brand Family Calbiochem®
SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
References
ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.
Product Information
CAS number733009-42-2
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₆H₁₀Cl₃FN₄O
Chemical formulaC₁₆H₁₀Cl₃FN₄O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
324833

Referencias bibliográficas

Visión general referencias
Shushan, A., et al. 2007. Fertil. Steril. 87, 127.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2011 RFH
SynonymsN-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
DescriptionA cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number733009-42-2
Chemical formulaC₁₆H₁₀Cl₃FN₄O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml). Use fresh, anhydrous DMSO.
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesShushan, A., et al. 2007. Fertil. Steril. 87, 127.