Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324761 Elastase Inhibitor V - Calbiochem

324761
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
324761-25MG Frasco de vidrio 25 mg
Description
OverviewA benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.).
Catalogue Number324761
Brand Family Calbiochem®
Synonyms2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
References
ReferencesHsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.
Product Information
FormOff-white solid
Hill FormulaC₁₄H₇BrClNO₂
Chemical formulaC₁₄H₇BrClNO₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetElastase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Elastase Inhibitor V - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2013 JSW
Synonyms2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
DescriptionA benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₇BrClNO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml). Use only fresh DMSO.
Storage +2°C to +8°C
Protect from moisture
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.