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341253 FAAH Inhibitor III, URB937 - Calbiochem

341253
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
341253-5MG Frasco de vidrio 5 mg
Description
OverviewA blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).
Catalogue Number341253
Brand Family Calbiochem®
SynonymsCyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester
References
ReferencesClapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.
Product Information
FormGrey-white powder
Hill FormulaC₂₀H₂₂N₂O₄
Chemical formulaC₂₀H₂₂N₂O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FAAH Inhibitor III, URB937 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Clapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-May-2013 JSW
SynonymsCyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester
DescriptionA blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).
FormGrey-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₂N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesClapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.