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344079 Flurbiprofen - CAS 5104-49-4 - Calbiochem

344079
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₅H₁₃FO₂ 5104-49-4

Products

Número de referenciaEmbalaje Cant./Env.
344079-100MG Tambor de alum 100 mg
Description
OverviewA mixture of S(+) and R(–) enantiomers. A cell-permeable, non-steroidal anti-inflammatory agent that acts as a potent inhibitor of cyclooxygenase (IC50 = 5 nM for LPS-induced COX in human peripheral blood cells). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Suppresses iNOS expression in RAW 264.7 macrophages. Reduces microglial activation and β-amyloid deposit in APP+PS1 transgenic mice.
Catalogue Number344079
Brand Family Calbiochem®
Synonyms(±)-2-Fluoro-α-methyl[1,1ʹ-biphenyl]-4-acetic Acid, U-27182
References
ReferencesJantzen, P.T., et al. 2002. J. Neurosci. 22, 2246.
Hinz, R., et al. 2001. Pharmacol. Res. 18, 151.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Range, S.P., et al. 2000. Eur. Respir. J. 15, 751.
van Haeringen, N.J., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 353.
Curnock, A.P., et al. 1997. J. Pharmacol. Exp. Ther. 282, 339.
Reindeau, D., et al. 1997. Can. J. Physiol. Pharmacol. 75, 1088.
Wechter, W.J., et al. 1997. Cancer Res. 57, 4316.
Karmali, R.A., and Marsh, J. 1986. Prostaglandins Leukot. Med. 23, 11.
Karmali, R.A., and Marsh, J. 1985. Prostaglandins Leukot. Med. 20, 283.
Product Information
CAS number5104-49-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₁₃FO₂
Chemical formulaC₁₅H₁₃FO₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCyclooxygenase
Primary Target IC<sub>50</sub>5 nM for LPS-induced COX
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDU8341000
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at 4°C. Further dilution of stock solution in aqueous medium should be made just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Flurbiprofen - CAS 5104-49-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Flurbiprofen - CAS 5104-49-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
344079

Referencias bibliográficas

Visión general referencias
Jantzen, P.T., et al. 2002. J. Neurosci. 22, 2246.
Hinz, R., et al. 2001. Pharmacol. Res. 18, 151.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Range, S.P., et al. 2000. Eur. Respir. J. 15, 751.
van Haeringen, N.J., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 353.
Curnock, A.P., et al. 1997. J. Pharmacol. Exp. Ther. 282, 339.
Reindeau, D., et al. 1997. Can. J. Physiol. Pharmacol. 75, 1088.
Wechter, W.J., et al. 1997. Cancer Res. 57, 4316.
Karmali, R.A., and Marsh, J. 1986. Prostaglandins Leukot. Med. 23, 11.
Karmali, R.A., and Marsh, J. 1985. Prostaglandins Leukot. Med. 20, 283.

Folleto

Cargo
Alzheimer's Disease Brochure & Technical Guide
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-October-2017 JSW
Synonyms(±)-2-Fluoro-α-methyl[1,1ʹ-biphenyl]-4-acetic Acid, U-27182
DescriptionA mixture of S(+) and R(-) enantiomers. A cell-permeable, non-steroidal anti-inflammatory (NSAID) agent that acts as a potent inhibitor of cyclooxygenase (IC50 = 5 nM for LPS-induced COX in human peripheral blood cells). The S(+) enantiomer is reported to be more potent as a COX-2 inhibitor than the R(-) enantiomer. Suppresses iNOS expression in RAW 264.7 macrophages. Reduces Aβ loads and Congo Red staining in APP+PS1 transgenic mice
FormWhite solid
CAS number5104-49-4
RTECSDU8341000
Chemical formulaC₁₅H₁₃FO₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at 4°C. Further dilution of stock solution in aqueous medium should be made just prior to use.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 4199
ReferencesJantzen, P.T., et al. 2002. J. Neurosci. 22, 2246.
Hinz, R., et al. 2001. Pharmacol. Res. 18, 151.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Range, S.P., et al. 2000. Eur. Respir. J. 15, 751.
van Haeringen, N.J., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 353.
Curnock, A.P., et al. 1997. J. Pharmacol. Exp. Ther. 282, 339.
Reindeau, D., et al. 1997. Can. J. Physiol. Pharmacol. 75, 1088.
Wechter, W.J., et al. 1997. Cancer Res. 57, 4316.
Karmali, R.A., and Marsh, J. 1986. Prostaglandins Leukot. Med. 23, 11.
Karmali, R.A., and Marsh, J. 1985. Prostaglandins Leukot. Med. 20, 283.