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324877 Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem

324877
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₆H₁₀N₄ • 4HCl 4506-66-5

Products

Número de referenciaEmbalaje Cant./Env.
324877-5MG 5 mg
Description
OverviewA cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC50 <1 µM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC50 ~10 µM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).
Catalogue Number324877
Brand Family Calbiochem®
SynonymsFAK Inhibitor I, 1,2,4,5-Benzenetetraamine, 4HCl, NSC 667249
References
ReferencesGolubovskaya, V.M., et al. 2008. J. Med. Chem. 51, 7405.
Product Information
CAS number4506-66-5
FormGrey solid
Hill FormulaC₆H₁₀N₄ • 4HCl
Chemical formulaC₆H₁₀N₄ • 4HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by elemental analysis
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
324877

Referencias bibliográficas

Visión general referencias
Golubovskaya, V.M., et al. 2008. J. Med. Chem. 51, 7405.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-June-2010 RFH
SynonymsFAK Inhibitor I, 1,2,4,5-Benzenetetraamine, 4HCl, NSC 667249
DescriptionA cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC50 <1 µM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC50 ~10 µM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).
FormGrey solid
Intert gas (Yes/No) Packaged under inert gas
CAS number4506-66-5
Chemical formulaC₆H₁₀N₄ • 4HCl
Structure formulaStructure formula
Purity≥95% by elemental analysis
SolubilityH₂O (14 mg/ml) or DMSO (50 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGolubovskaya, V.M., et al. 2008. J. Med. Chem. 51, 7405.