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344273 Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

344273
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₉H₄₈N₂O₇ · 2HCl 115116-37-5

Products

Número de referenciaEmbalaje Cant./Env.
344273-10MG Ampolla de plást. 10 mg
344273-5MG Ampolla de plást. 5 mg
Description
OverviewChemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.
Catalogue Number344273
Brand Family Calbiochem®
SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
References
ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
Product Information
CAS number115116-37-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₄₈N₂O₇ · 2HCl
Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
ApplicationForskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, CAS 115116-37-5, is a chemically-modified forskolin for greater stability and water solubility.
Biological Information
Primary TargetAdenylate cyclase
Primary Target IC<sub>50</sub>EC50 = 13 µM in activating adenylate cyclase
Purity≥92% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 21

Harmful in contact with skin.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
344273

Referencias bibliográficas

Visión general referencias
Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.

Folleto

Cargo
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
DescriptionA chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC50 = 13 µM).
FormWhite solid
CAS number115116-37-5
Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
Structure formulaStructure formula
Purity≥92% by HPLC
SolubilityMethanol or H₂O (12 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Toxicity Harmful
ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.