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344850 Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

344850
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₃₄H₅₉NO₁₅ 116355-83-0

Products

Número de referenciaEmbalaje Cant./Env.
344850-1MG Ampolla de plást. 1 mg
Description
OverviewA cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
Catalogue Number344850
Brand Family Calbiochem®
SynonymsFB₁
References
ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
Riley, R.T., et al. 1994. J. Nutr. 124, 594.
Wolf, G. 1994. Nutr. Rev. 52, 246.
Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
Product Information
CAS number116355-83-0
ATP CompetitiveN
FormWhite to beige powder
Hill FormulaC₃₄H₅₉NO₁₅
Chemical formulaC₃₄H₅₉NO₁₅
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetceramide synthase
Primary Target IC<sub>50</sub>100 nM against sphingosine N-acyltransferase (ceramide synthase)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTZ8350000
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 22-26-36/37/39

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
344850

Referencias bibliográficas

Visión general referencias
Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
Riley, R.T., et al. 1994. J. Nutr. 124, 594.
Wolf, G. 1994. Nutr. Rev. 52, 246.
Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

Citas

Título
  • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision30-January-2017 JSW
    SynonymsFB₁
    DescriptionFumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
    FormWhite to beige powder
    CAS number116355-83-0
    RTECSTZ8350000
    Chemical formulaC₃₄H₅₉NO₁₅
    Structure formulaStructure formula
    Purity≥95% by TLC
    SolubilityMethanol (5 mg/ml)
    Storage +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Carcinogenic / Teratogenic
    Merck USA index14, 4289
    ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
    Riley, R.T., et al. 1994. J. Nutr. 124, 594.
    Wolf, G. 1994. Nutr. Rev. 52, 246.
    Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
    Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
    Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
    Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
    Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
    Citation
  • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.