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344932 Furin, Human, Recombinant

344932
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Products

Número de referenciaEmbalaje Cant./Env.
344932-50UL Ampolla de plást. 50 ul
Description
OverviewRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Supplied as a crude preparation of soluble furin obtained from cytoplasmic extracts. Furin is a type I membrane protein that processes stromelysin-3 (MMP-11) and MT1-MMP. It cleaves pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins.
This preparation was subjected to UV irradiation for 5 min to inactivate any residual vaccinia virus.
Catalogue Number344932
Brand Family Calbiochem®
References
ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
Product Information
Unit of DefinitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
FormLiquid
FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Furin, Human, Recombinant Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Furin, Human, Recombinant Certificados de análisis

CargoNúmero de lote
344932

Referencias bibliográficas

Visión general referencias
Bassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-January-2008 JSW
DescriptionRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like pro-hormone convertase (PC) family. Members of this family cleave pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins. The preparation was subjected to UV irradiation for 5 minutes to inactivate any residual virus.
FormLiquid
FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
Unit definitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
Storage ≤ -70°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.