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361547 GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem

361547
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₆H₃Br₂ClOS 62673-69-2

Products

Número de referenciaEmbalaje Cant./Env.
361547-5MG Ampolla de plást. 5 mg
Description
OverviewA thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
Catalogue Number361547
Brand Family Calbiochem®
Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
References
ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
Product Information
CAS number62673-69-2
ATP CompetitiveN
FormOrange solid
Hill FormulaC₆H₃Br₂ClOS
Chemical formulaC₆H₃Br₂ClOS
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetGsk-3β
Primary Target IC<sub>50</sub>1 µM against Gsk-3β
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
361547

Referencias bibliográficas

Visión general referencias
Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
DescriptionA cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number62673-69-2
Chemical formulaC₆H₃Br₂ClOS
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml). Use fresh, anhydrous DMSO only.
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
Toxicity Standard Handling
ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.