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345733 Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

345733
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₆₄H₁₁₈N₂O₂₁ · NH₄

Products

Número de referenciaEmbalaje Cant./Env.
345733-500UG Ampolla de plást. 500 μg
Description
OverviewContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
M.W. 1198.5 (based on stearoyl - 18:0).
Catalogue Number345733
Brand Family Calbiochem®
SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
References
ReferencesKatoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₆₄H₁₁₈N₂O₂₁ · NH₄
Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetProtein kinase C, EGF-receptor tyrosine kinase
Primary Target IC<sub>50</sub>100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Certificados de análisis

CargoNúmero de lote
345733

Referencias bibliográficas

Visión general referencias
Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

Folleto

Cargo
Gangliosides Technical Bulletin
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2007 RFH
SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
DescriptionContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC50 = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
FormWhite solid
Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityChloroform:Methanol (2:1)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesKatoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.