Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

371545 Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

371545
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₀H₁₂N₅O₁₃P₃S . 4Li 94825-44-2

Products

Número de referenciaEmbalaje Cant./Env.
371545-10MG Frasco de vidrio 10 mg
Description
OverviewG-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
Catalogue Number371545
Brand Family Calbiochem®
SynonymsGTPγ-S, 4Li
References
ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
Product Information
CAS number94825-44-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetG-protein-activating GTP analog
Purity≥85% by HPLC.
Physicochemical Information
Cell permeableN
ContaminantsGDP: ≤12%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
371545

Referencias bibliográficas

Visión general referencias
Iino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2009 JSW
SynonymsGTPγ-S, 4Li
DescriptionG-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P3 formation in membranes.
FormWhite solid
CAS number94825-44-2
Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Structure formulaStructure formula
Purity≥85% by HPLC.
ContaminantsGDP: ≤12%
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
Toxicity Standard Handling
ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.