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373273 Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem

373273
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₆H₂₆ClN₃O₄ 329196-48-7

Products

Número de referenciaEmbalaje Cant./Env.
373273-10MG 10 mg
Description
OverviewA nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
Catalogue Number373273
Brand Family Calbiochem®
SynonymsN-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V
References
ReferencesRominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Product Information
CAS number329196-48-7
FormWhite powder
Hill FormulaC₂₆H₂₆ClN₃O₄
Chemical formulaC₂₆H₂₆ClN₃O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
373273

Referencias bibliográficas

Visión general referencias
Rominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsN-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V
DescriptionA nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number329196-48-7
Chemical formulaC₂₆H₂₆ClN₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.