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220491 InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

220491
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₀H₁₄ClN₃O₂ 516480-79-8

Products

Número de referenciaEmbalaje Cant./Env.
220491-5MG Frasco de vidrio 5 mg
Description
OverviewA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
Catalogue Number220491
Brand Family Calbiochem®
Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
References
ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
Product Information
CAS number516480-79-8
FormLiquid
FormulationSupplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
Hill FormulaC₂₀H₁₄ClN₃O₂
Chemical formulaC₂₀H₁₄ClN₃O₂
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
220491

Referencias bibliográficas

Visión general referencias
Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
DescriptionA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
FormLiquid
FormulationSupplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number516480-79-8
Chemical formulaC₂₀H₁₄ClN₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.