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234491 InSolution™ PD 153035 - Calbiochem

234491
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₆H₁₄BrN₃O₂

Products

Número de referenciaEmbalaje Cant./Env.
234491-500UG Ampolla de plást. 500 μg
Description
Catalogue Number234491
Brand Family Calbiochem®
References
Product Information
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
FormLiquid
FormulationA 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
Hill FormulaC₁₆H₁₄BrN₃O₂
Chemical formulaC₁₆H₁₄BrN₃O₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>25 pM
Primary Target K<sub>i</sub>6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ PD 153035 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

InSolution™ PD 153035 - Calbiochem Certificados de análisis

CargoNúmero de lote
234491
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-June-2008 RFH
DescriptionAn extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
FormLiquid
FormulationA 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₁₄BrN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant