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370681 OXE-R-Gβγ Coupling Modulator, Gue1654 - Calbiochem

370681
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
370681-25MG Frasco de vidrio 25 mg
Description
OverviewA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Gαβ interaction. Selectively inhibits OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream cellular signalings (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
Catalogue Number370681
Brand Family Calbiochem®
Synonyms7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole, N-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide
References
ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
Product Information
FormTan solid
Hill FormulaC₂₃H₁₇N₃OS₃
Chemical formulaC₂₃H₁₇N₃OS₃
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Target OXE-R-Gβγ coupling
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

OXE-R-Gβγ Coupling Modulator, Gue1654 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Blattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2013 JSW
Synonyms7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole, N-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide
DescriptionA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, but not preexisting OXE-R-Gαβ interaction. Shown to selectively inhibit OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream signalings in HEK293 as well as primary human eosinophils and neutrophils (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs, including PGD2 receptor CRTH2 (DP2), IL8 receptors CXCR1/2, muscarinic receptor, and C5a receptor. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₁₇N₃OS₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.