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203701 bpV(HOpic) - Calbiochem

203701
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
K₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O

Products

Número de referenciaEmbalaje Cant./Env.
203701-5MG Ampolla de plást. 5 mg
Description
OverviewA potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Catalogue Number203701
Brand Family Calbiochem®
SynonymsDipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
References
ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Product Information
ATP CompetitiveN
FormYellow solid
Hill FormulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
Chemical formulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
ReversibleN
Structure formula ImageStructure formula Image
Applications
ApplicationbpV(HOpic), CAS 722494-26-0, is a potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Biological Information
Primary TargetPTEN
Primary Target IC<sub>50</sub>14 nM
Purity≥70% by ⁵¹V-NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

bpV(HOpic) - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

bpV(HOpic) - Calbiochem Certificados de análisis

CargoNúmero de lote
203701

Referencias bibliográficas

Visión general referencias
Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Folleto

Cargo
Protein Phosphatases Technical Bulletin
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2015 JSW
SynonymsDipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
DescriptionA potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaK₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
Structure formulaStructure formula
Purity≥70% by ⁵¹V-NMR
SolubilityH₂O (4 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.