239764 | Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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      Overview

      Tabla espec. clave

      Empirical Formula CAS #

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      239764-100MG
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          100 mg
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          239764-1GM
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              1 gm
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              Description
              Overview Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
              Catalogue Number
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              References
              References Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Product Information
              CAS number
              Form White solid
              Hill Formula
              Chemical formula
              Molar Mass 281.3
              Structure formula Image
              Applications
              Biological Information
              Primary Target hFKBP12
              Primary Target Ki 3.4 µM
              Purity ≥98% by HPLC
              Physicochemical Information
              Solubility EtOH or MeOH
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECS
              Safety Information
              R Phrase R: 28-40-51/53-61

              Very toxic if swallowed.
              Limited evidence of a carcinogenic effect.
              Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
              May cause harm to the unborn child.
              S Phrase S: 45-53-61

              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Avoid exposure - obtain special instructions before use.
              Avoid release to the environment. Refer to special instructions/safety data sheet.
              Product Usage Statements
              Storage and Shipping Information
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              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Ficha datos de seguridad (MSDS)

              Idiomas
              Argentina Australia Belgie
              Belgien Belgique Brasil
              Canadian English Canadian-French Ceská Rep
              Chile China Colombia
              Cyprus Danmark Deutschland
              Eesti Ellas English
              España España France
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              South Africa Srpski Standard EU English
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              Svizzera Taiwan Thailand
              Türkiye US English United Kingdom
              Venezuela Vietnamese Éire
              Österreich България Россия

              Certificados de análisis

              CargoNúmero de lote
              239764

              Referencias bibliográficas

              Visión general referencias
              Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.

              Folleto

              Cargo
              Tools and Tips for Analyzing Apoptosis

              Citas

              Título
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
            • Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 29-April-2008 RFH
              Description Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
              Form White solid
              CAS number
              RTECS
              Molar mass 281.3
              Chemical formula
              Structure formula
              Purity ≥98% by HPLC
              Solubility Chloroform, Ethanol, and Methanol
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              Pagelet <feature_storage_value-> no encontrado.
              Error configuración datos. Pagelet <feature_clustercode_donotfreeze-> no encontrado.
              Pagelet <feature_storage_value-> no encontrado.
              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Error configuración datos. Pagelet <feature_clustercode_toxicity-> no encontrado.
              Pagelet <feature_storage_value-> no encontrado.
              Merck USA index
              References Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Citation