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324515 eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

324515
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₇H₄₅IN₂ 278603-08-0

Products

Número de referenciaEmbalaje Cant./Env.
324515-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
Catalogue Number324515
Brand Family Calbiochem®
Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
References
ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
Arora, S., et al. 2003. Cancer Res. 63, 6894.
Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
Product Information
CAS number278603-08-0
ATP CompetitiveN
FormYellow solid
Hill FormulaC₂₇H₄₅IN₂
Chemical formulaC₂₇H₄₅IN₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetBacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Primary Target IC<sub>50</sub>60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
324515

Referencias bibliográficas

Visión general referencias
Arora, S., et al. 2004. Mol. Pharmacol. 66, 460.
Arora, S., et al. 2003. Cancer Res. 63, 6894.
Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-June-2009 RFH
Synonyms1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
DescriptionA cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC50 = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC50 = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number278603-08-0
Chemical formulaC₂₇H₄₅IN₂
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityDMSO (20 mg/ml) or 70% Ethanol (5 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesArora, S., et al. 2004. Mol. Pharmacol. 66, 460.
Arora, S., et al. 2003. Cancer Res. 63, 6894.
Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.