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324516 eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

324516
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₃H₁₅N₅O₃ 142557-61-7

Products

Número de referenciaEmbalaje Cant./Env.
324516-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Catalogue Number324516
Brand Family Calbiochem®
Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
References
ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
Product Information
CAS number142557-61-7
FormOff-white powder
Hill FormulaC₁₃H₁₅N₅O₃
Chemical formulaC₁₃H₁₅N₅O₃
Structure formula ImageStructure formula Image
Applications
ApplicationeEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
324516

Referencias bibliográficas

Visión general referencias
Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2012 JSW
Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
DescriptionA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number142557-61-7
Chemical formulaC₁₃H₁₅N₅O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (2.5 mg/ml; clear, colorless solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.