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324517 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

324517
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₈H₁₂Cl₂N₄O₄S 315706-13-9

Products

Número de referenciaEmbalaje Cant./Env.
324517-10MG Ampolla de plást. 10 mg
Description
OverviewA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).
Catalogue Number324517
Brand Family Calbiochem®
Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
References
ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
Product Information
CAS number315706-13-9
FormYellow solid
Hill FormulaC₁₈H₁₂Cl₂N₄O₄S
Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
Structure formula ImageStructure formula Image
Applications
ApplicationeIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
Biological Information
Purity≥98% by HPLC (sum of two isomers)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
324517

Referencias bibliográficas

Visión general referencias
Moerke, N. J., et al. 2007. Cell 128, 257.

Citas

Título
  • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
  • Hoeffer et al. 2011. PNAS
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision11-December-2013 JSW
    Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
    DescriptionA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM).
    FormYellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number315706-13-9
    Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
    Structure formulaStructure formula
    Purity≥98% by HPLC (sum of two isomers)
    SolubilityDMSO (100 mg/ml)
    Storage +2°C to +8°C
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Harmful
    ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
    Citation
  • Hoeffer, C.A., et al. 2011. PNAS 8 3383.
  • Hoeffer et al. 2011. PNAS