525185 | Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

525185
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      Overview

      Tabla espec. clave

      Empirical Formula CAS #

      Precios y disponibilidad

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      525185-10MG
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          10 mg
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          Description
          Overview A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
          Catalogue Number
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          Synonyms m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
          References
          References Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
          Product Information
          CAS number
          ATP Competitive
          Form Off-white solid
          Hill Formula
          Chemical formula
          Molar Mass 343.4
          Reversible
          Structure formula Image
          Applications
          Biological Information
          Primary Target Phospholipase C (PLC)
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
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          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
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          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Idiomas
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          Certificados de análisis

          CargoNúmero de lote
          525185

          Referencias bibliográficas

          Visión general referencias
          Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.

          Citas

          Título
        • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 26-August-2008 RFH
          Synonyms m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
          Description A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
          Form Off-white solid
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          Pagelet <null> no encontrado.
          CAS number
          Molar mass 343.4
          Chemical formula
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (7 mg/ml)
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          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
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          References Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
          Citation