692000 | ZM 336372 - CAS 208260-29-1 - Calbiochem

692000
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      Overview

      Replacement Information

      Tabla espec. clave

      Empirical Formula CAS #
      C₂₃H₂₃N₃O₃ 208260-29-1

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      692000-1MG
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          1 mg
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          Description
          Overview A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
          Catalogue Number 692000
          Brand Family Calbiochem®
          Synonyms N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
          References
          References Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.
          Product Information
          CAS number 208260-29-1
          ATP Competitive Y
          Declaration Sold under license of PCT Application W098/22,103.
          Form Off-white solid
          Hill Formula C₂₃H₂₃N₃O₃
          Chemical formula C₂₃H₂₃N₃O₃
          Molar Mass 389.4
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target Protein kinase c-Raf
          Primary Target IC50 70 nM against protein kinase c-Raf
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Title

          Material Safety Data Sheet (MSDS)  

          Certificados de análisis

          CargoNúmero de lote
          692000

          Referencias bibliográficas

          Visión general referencias
          Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 13-January-2010 RFH
          Synonyms N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
          Description A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
          Form Off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 208260-29-1
          Molar mass 389.4
          Chemical formula C₂₃H₂₃N₃O₃
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Toxicity Standard Handling
          References Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.