104551 ACC2 Inhibitor, CD-017-0191 - Calbiochem

104551
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₀H₁₉N₃O₃S

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      104551-10MG
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      In Stock 
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
          Catalogue Number104551
          Brand Family Calbiochem®
          Synonyms2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
          References
          ReferencesMarjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.
          Product Information
          FormOff-white solid
          Hill FormulaC₂₀H₁₉N₃O₃S
          Chemical formulaC₂₀H₁₉N₃O₃S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          104551

          References

          Reference overview
          Marjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-February-2011 RFH
          Synonyms2-((2-(4-isopropoxyphenyl)-5-methyloxazol-4-yl)methylthio)oxazolo[4,5-b]pyridine
          DescriptionA cell-permeable and selective inhibitor of human Acetyl-CoA carboxylase 2 (ACC2) (IC50 = 2.8 µM), which does not inhibit human ACC1 at all at concentrations up to 100 µM, in vitro. It is also shown to inhibit the growth of yeast (IC50 = 3.8 µM), in which the native ACC1 gene is replaced with the human ACC2 strain; but not with the human ACC1 strain at concentrations ≤ 100 µM. This compound is not demonstrated to be toxic to human cells in culture at concentrations up to 10 µM.
          FormOff-white solid
          Chemical formulaC₂₀H₁₉N₃O₃S
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMarjanovic, J., et al. 2010 Proc. Natl. Acad. Sci. 107, 9093.