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114825 Adapalene - CAS 106685-40-9 - Calbiochem

114825
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈H₂₈O₃106685-40-9

Products

Catalogue NumberPackaging Qty/Pack
114825-25MG 25 mg
Description
OverviewA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
Catalogue Number114825
Brand Family Calbiochem®
SynonymsDifferin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA
References
ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
Product Information
CAS number106685-40-9
FormWhite solid
Hill FormulaC₂₈H₂₈O₃
Chemical formulaC₂₈H₂₈O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adapalene - CAS 106685-40-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adapalene - CAS 106685-40-9 - Calbiochem Certificates of Analysis

TitleLot Number
114825

References

Reference overview
Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-September-2010 RFH
SynonymsDifferin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA
DescriptionA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number106685-40-9
Chemical formulaC₂₈H₂₈O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (12 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.

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Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Vitamins, Coenzymes and Cofactors