116805 PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem

116805
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₉₄H₁₄₈N₃₂O₃₁99534-03-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      116805-500UG
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      In Stock 
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          Plastic ampoule 500 μg
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          Description
          OverviewA potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
          Catalogue Number116805
          Brand Family Calbiochem®
          SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
          References
          ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
          Product Information
          CAS number99534-03-9
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
          Hill FormulaC₉₄H₁₄₈N₃₂O₃₁
          Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetPKA
          Primary Target K<sub>i</sub>2.3 nM for protein kinase A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          116805

          References

          Reference overview
          Knighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
          DescriptionPeptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM).
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
          CAS number99534-03-9
          Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
          Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml). Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
          Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
          Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
          Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.