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05-23-2101 Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem

05-23-2101
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄₇H₂₃₈N₄₄O₄₂S40077-57-4

Products

Catalogue NumberPackaging Qty/Pack
05-23-2101-0.5MG Plastic ampoule .5 mg
05-23-2101-1MG Glass bottle 1 mg
Description
OverviewActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.
Catalogue Number05-23-2101
Brand Family Calbiochem®
SynonymsVIP
References
ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
Grider, J.R. 1993. Am. J. Physiol. 264, G334.
Product Information
CAS number40077-57-4
ATP CompetitiveN
FormWhite to off-white lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₄₇H₂₃₈N₄₄O₄₂S
Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Applications
Biological Information
Primary TargetMitogenic factor for embryonic neurons
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem Certificates of Analysis

TitleLot Number
05-23-2101

References

Reference overview
Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
Grider, J.R. 1993. Am. J. Physiol. 264, G334.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-September-2008 RFH
SynonymsVIP
DescriptionActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Nitric oxide stimulates the release of this peptide. Inhibits human small-cell lung carcinoma (SCLC) in nude mice both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC.
FormWhite to off-white lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
CAS number40077-57-4
Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
Purity≥95% by HPLC
Solubility5% Acetic acid (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
Grider, J.R. 1993. Am. J. Physiol. 264, G334.