116860 Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem

116860
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₁H₁₆N₄O₄ 53910-25-1

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      116860-10MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
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          Flacon en verre 10 mg
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          Description
          OverviewA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
          Catalogue Number116860
          Brand Family Calbiochem®
          Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
          References
          ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
          Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
          Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
          Product Information
          CAS number53910-25-1
          FormWhite solid
          Hill FormulaC₁₁H₁₆N₄O₄
          Chemical formulaC₁₁H₁₆N₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 62-63

          Possible risk of impaired fertility.
          Possible risk of harm to the unborn child.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Harmful & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          116860

          Références bibliographiques

          Aperçu de la référence bibliographique
          Robak, T. 2007. Cancer Treat. Rev. 33, 710.
          Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
          Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-May-2012 JSW
          Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
          DescriptionA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number53910-25-1
          Chemical formulaC₁₁H₁₆N₄O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml; clear, colorless solution) or H₂O (50 mg/ml; clear, colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
          Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
          Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.