116890 | Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem

116890
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      Empirical FormulaCAS #
      C₂₂H₁₉BrN₆O 214697-26-4

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      116890-5MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
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          Ampoule plast. 5 mg
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          Description
          OverviewA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without salt molecules.
          Catalogue Number116890
          Brand Family Calbiochem®
          Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
          References
          ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
          Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
          Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
          Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
          Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
          Product Information
          CAS number214697-26-4
          ATP CompetitiveN
          FormYellow to orange solid
          Hill FormulaC₂₂H₁₉BrN₆O
          Chemical formulaC₂₂H₁₉BrN₆O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAdenosine Kinase
          Primary Target IC<sub>50</sub>50.7 nM inhibiting adenosine kinase (AK) using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          116890

          Références bibliographiques

          Aperçu de la référence bibliographique
          De Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
          Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
          Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
          Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
          Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-October-2009 JSW
          Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
          DescriptionA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).
          FormYellow to orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number214697-26-4
          Chemical formulaC₂₂H₁₉BrN₆O
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
          Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
          Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
          Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
          Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.