129874 | Amifostine - CAS 20537-88-6 - Calbiochem

129874
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      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₅H₁₅N₂O₃PS •3H₂O 20537-88-6

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      129874-50MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients

          Flacon en verre 50 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          Description
          OverviewA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
          Catalogue Number129874
          Brand Family Calbiochem®
          Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
          References
          ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
          Product Information
          CAS number20537-88-6
          FormOff-white solid
          Hill FormulaC₅H₁₅N₂O₃PS •3H₂O
          Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          129874

          Références bibliographiques

          Aperçu de la référence bibliographique
          Dedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-May-2012 JSW
          Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
          DescriptionA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number20537-88-6
          Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
          Structure formulaStructure formula
          Purity≥99% by NMR
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
          Yoon, Y.D., et al. 2005. In Vivo 19, 509.
          Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
          Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.