176900 | Anthrax Lethal Factor, Recombinant, Bacillus anthracis, B. anthracis - Calbiochem

176900
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      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      176900-100UG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
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          Contacter le Service Clients

          Ampoule plast. 100 μg
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          Description
          OverviewRecombinant, Bacillus anthracis anthrax lethal factor expressed in a specialized strain of B. anthracis. One of the three protein components of Anthrax toxin, lethal factor (LF) is a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family. LF is comprised of four domains. Domain I binds the protective antigen to enter the target cell; domains II, III, and IV create a long groove to hold and cleave the MAPKK proteins.
          Catalogue Number176900
          Brand Family Calbiochem®
          References
          ReferencesBrossier, F., and Mock, M. 2001. Toxicon 39, 1747.
          Friedlander, A.M. 2001. Nature 414, 160.
          Gupta, P., et al. 2001. Biochem. Biophys. Res. Commun. 284, 568.
          Pannifer, A.D., et al. 2001. Nature 414, 160.
          Pugsley, A.P. 1996. Proc. Natl. Acad. Sci. USA 93, 8155.
          Leppla, S.H. 1991. Methods Enzymol. 195, 153.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme required to catalyze the release of 1.0 pmole of cleaved MAPKKide™ substrate per min at 37°C, in 20 mM HEPES, pH 8.2.
          FormLyophilized
          FormulationLyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
          Applications
          Biological Information
          Primary TargetMAPKK
          PuritySingle major band by SDS-PAGE
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
          End use certificateY
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          176900

          Références bibliographiques

          Aperçu de la référence bibliographique
          Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.
          Friedlander, A.M. 2001. Nature 414, 160.
          Gupta, P., et al. 2001. Biochem. Biophys. Res. Commun. 284, 568.
          Pannifer, A.D., et al. 2001. Nature 414, 160.
          Pugsley, A.P. 1996. Proc. Natl. Acad. Sci. USA 93, 8155.
          Leppla, S.H. 1991. Methods Enzymol. 195, 153.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-October-2013 JSW
          DescriptionRecombinant, Bacillus anthracis anthrax lethal factor expressed in a special strain of B. anthracis. One of three protein components of anthrax toxin produced by the pathogenic bacterium, Bacillus anthracis. Highly specific protease component that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family. LF is comprised of four domains: domain I that binds to protective antigen (necessary for entry into the cellular target) and domains II, III, and IV which form a long groove to hold and cleave the target proteins. Requires passage through an acidic vesicle prior to translocation to the cytoplasm of the cell. Cleavage of target proteins leads to the inhibition of multiple signaling pathways and cell death.
          FormLyophilized
          FormulationLyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
          PuritySingle major band by SDS-PAGE
          Unit definitionOne unit is defined as the amount of enzyme required to catalyze the release of 1.0 pmole of cleaved MAPKKide™ substrate per min at 37°C, in 20 mM HEPES, pH 8.2.
          SolubilityPlease refer to the vial label for lot-specific reconstitution volume.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBrossier, F., and Mock, M. 2001. Toxicon 39, 1747.
          Friedlander, A.M. 2001. Nature 414, 160.
          Gupta, P., et al. 2001. Biochem. Biophys. Res. Commun. 284, 568.
          Pannifer, A.D., et al. 2001. Nature 414, 160.
          Pugsley, A.P. 1996. Proc. Natl. Acad. Sci. USA 93, 8155.
          Leppla, S.H. 1991. Methods Enzymol. 195, 153.