200275 | Berberine Chloride - CAS 633-65-8 - Calbiochem

200275
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      Empirical FormulaCAS #
      C₂₀H₁₈NO₄+Cl- 633-65-8

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      200275-25MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Flacon en verre 25 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
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          Description
          OverviewA highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
          Catalogue Number200275
          Brand Family Calbiochem®
          SynonymsBerberine
          References
          ReferencesKinm. B., et al. 2011, Brit. Journ. Pharm.164, 106.
          Kong, W., et al. 2004, Nature Med. 10, 1344.
          Dimlich, R. et al. 1980, Stain Technol. 55, 217.
          Product Information
          CAS number633-65-8
          FormYellow powder
          Hill FormulaC₂₀H₁₈NO₄+Cl-
          Chemical formulaC₂₀H₁₈NO₄+Cl-
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC (NMR if no UV signal)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          200275

          Références bibliographiques

          Aperçu de la référence bibliographique
          Kinm. B., et al. 2011, Brit. Journ. Pharm.164, 106.
          Kong, W., et al. 2004, Nature Med. 10, 1344.
          Dimlich, R. et al. 1980, Stain Technol. 55, 217.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2012 JSW
          SynonymsBerberine
          DescriptionA highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number633-65-8
          Chemical formulaC₂₀H₁₈NO₄+Cl-
          Structure formulaStructure formula
          Purity≥95% by HPLC (NMR if no UV signal)
          SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKinm. B., et al. 2011, Brit. Journ. Pharm.164, 106.
          Kong, W., et al. 2004, Nature Med. 10, 1344.
          Dimlich, R. et al. 1980, Stain Technol. 55, 217.