196871 InSolution™ BAY 11-7082 - Calbiochem

196871
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₀H₉NO₂S

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      196871-10MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Ampoule plast. 10 mg
          Prix en cours de récupération
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          Description
          Catalogue Number196871
          Brand Family Calbiochem®
          References
          ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
          Hill FormulaC₁₀H₉NO₂S
          Chemical formulaC₁₀H₉NO₂S
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTNF-α-inducible phosphorylation of IκBα
          Primary Target IC<sub>50</sub>10 µM
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          196871

          Références bibliographiques

          Aperçu de la référence bibliographique
          Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

          Citations

          Titre
        • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
        • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
          FormLiquid
          FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₀H₉NO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Toxicity Irritant
          ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
          Citation
        • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
        • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.