119114 Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem

119114
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      Empirical FormulaCAS #
      C₁₅H₁₄N₂S 10205-56-8

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      119114-5MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
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          Flacon en verre 5 mg
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          Description
          OverviewA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
          Catalogue Number119114
          Brand Family Calbiochem®
          Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
          References
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Product Information
          CAS number10205-56-8
          DeclarationMarketed by Promega Corp. under the registered trademarks.
          FormPale green solid
          Hill FormulaC₁₅H₁₄N₂S
          Chemical formulaC₁₅H₁₄N₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Certificats d'analyse

          TitreNuméro de lot
          119114

          Références bibliographiques

          Aperçu de la référence bibliographique
          Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
          DescriptionA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
          FormPale green solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number10205-56-8
          Chemical formulaC₁₅H₁₄N₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (0.5 mg/ml) or Ethanol (3 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.