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Mobius® FlexReady Solutions


Accelerate. Scale. Implement.
BioReliance® End-to-End Solutions

Speed Your Drug to the Clinic and the Market, Safely and Reliably

The Mobius® FlexReady Solutions offer you the flexibility to build an entire downstream single-use process train or incorporate individual unit operations for buffer and media preparation,  chromatography, clarification, ultrafiltration/diafiltration and virus filtration, to meet your unique processing challenges. This innovative single-use platform is designed to enable you to install equipment, configure applications and validate your processes quickly and easily.


Buffer and Media Preparation

Sterile filtration of your buffer and media is a critical step in your process. Sterilizing-grade filters remove bacteria and ensure sterility and safety of your filtrate. Mobius® single-use manufacturing provides you with a range of mixers, filtration platforms, connectology and storage options to meet your buffer and media preparation needs quickly and easily.

The Mobius® FlexReady Solution for Buffer and Media Preparation is an easy-to-use system featuring an optimized single-use flowpath designed to fully support your needs. It features a choice of Millipore Express® PES or Durapore® filters, which are ideally suited for buffer preparation and cell culture media filtration.

The Mobius® FlexReady Solution for Buffer and Media Preparation consists of single-use Flexware® assemblies, innovative separation devices and process-ready hardware systems to deliver optimal operational flexibility, from process development to clinical production to small-scale commercial manufacturing.

  • Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
  • Single-use flow paths provides maximum adaptability to your changing operational needs
  • Pre-designed and optimized solution for confidence and peace of mind



Chromatography

Chromatography Unit Operation Chromatography is critical to the successful purification of your drug. Mobius® single-use manufacturing offers a range of products, services and solutions that enable you to shorten your manufacturing time while continuing to offer the same level of purification performance. You can select from a range of single-use options including integrated separation platforms, mixers, connectors, storage containers and hardware

The Mobius® FlexReady Solution with Smart Flexware™ Assemblies for Chromatography is a fully automated system designed to achieve optimum performance during the purification of MAbs, vaccines, plasma and therapeutic proteins. The system features industry leading resins and single-use devices such as Fractogel® resin, Eshmuno® resin and ProSep® Ultra Plus resin.

The Mobius® FlexReady Solution with Smart Flexware™ Assemblies is the most flexible system available, allowing customers to have a single, scalable system that can switch between chromatography scales and tangen­tial flow filtration (TFF).

  • Smart Flexware™ 100% single-use assemblies provide ease-of-use, robust reproducibility, elimination of carryover from previous batches
  • Full process automation enables you to easily and reproducibly produce clinical and preclinical scale quantities of high-value drug products
  • Comprehensive services ensure rapid implementation and optimized performance



Clarification

The ultimate goal of clarification is to prepare the cell culture for downstream chromatography and purification. Mobius® single-use manufacturing offers a range of products, services and solutions to meet your particular clarification challenges. You can select from a range of single-use options including mixers, integrated filtration platforms, connectors, storage containers and hardware.

The Mobius® FlexReady Solution for Clarification is an easy-to-use system featuring an optimized single-use flowpath designed to fully support your clarification needs. It features Merck’s innovative, high-performance Millistak+® Pod disposable depth filters which are ideally suited for primary and secondary clarification.

The Mobius® FlexReady Solution for Clarification consists of single-use Flexware® assemblies, innovative separation devices and process-ready hardware systems to deliver optimal operational flexibility, from process development to clinical production to small-scale commercial manufacturing.

  • Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
  • Single-use flow paths provides maximum adaptability to your changing operational needs
  • Pre-designed and optimized solution for confidence and peace of mind




Ultrafiltration and Diafiltration

Mobius® FlexReady Solution featuring Smart Flexware™ Assemblies Ultrafiltration and diafiltration unit operation is a key step in your purification suite. Mobius® single-use manufacturing offers a wide range of products, services and solutions that enable you to shorten your manufacturing time while continuing to offer you the same level of filtration performance you rely upon from us. You can select from a range of single-use options including integrated filtration platforms, mixers, connectors, storage containers and hardware.

The Mobius® FlexReady Solution with Smart Flexware™ Assemblies for TFF is a fully automated system designed to achieve optimum performance during the purification of MAbs, vaccines, plasma and therapeutic proteins. The system features our leading Pellicon® cassettes. These advanced, high-performance devices are ideal for today’s higher titer therapeutic antibodies as well as the more demanding filtration processes that require higher operating pressures, temperatures and caustic cleaning regimes.

  • Standard hardware platform supports multi-unit operation, multi-product and multiscale production maximizing the flexibility of high-value investments
  • Smart Flexware™ single-use assemblies provide ease-of-use, robust reproducibility, elimination of carryover from previous batches
  • Full process automation enables you to easily and reproducibly produce clinical and preclinical scale quantities of high-value drug products
  • Comprehensive services ensure rapid implementation and optimized performance
  • Supports our industry leading devices




Virus Filtration

As a drug manufacturer you are required to ensure the virus safety of the biological therapeutics you have under development. Mobius® single-use manufacturing can help you meet your virus clearance requirements by providing not only the integrated filtation platforms but also the mixers, connectors, storage containers and hardware that will continue to provide you with the ability to process at increased throughputs.

The Mobius® FlexReady Solution for Virus Filtration is an easy-to-use system featuring an optimized single-use flowpath designed to fully support your parvovirus filtration needs. It features Viresolve® Pro Modus devices, a next-generation parvovirus safety solution delivering robust parvovirus clearance at pilot and medium volume processing.

The Mobius® FlexReady Solution for Virus Filtration con­sists of single-use Flexware® assemblies, innovative Viresolve Pro Modus devices and process-ready hardware systems to deliver optimal operational flexibility.

  • Fast setup of hardware with easy installation of optimally designed Flexware® assemblies
  • Single-use flow paths provides maximum adaptability to your changing operational needs
  • Pre-designed and optimized solution for confidence and peace of mind