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851011 | MSNT

851011
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Hill FormulaMolar Mass
      74257-00-4C₁₁H₁₂N₄O₄S296.31 g/mol

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      8510110001
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          Glas bottle pre packed 1 g
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          8510110005
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              Plastic bottle 5 g
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              8510110025
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                  Plastic bottle 25 g
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                  Description
                  Catalogue Number851011
                  Replaces01-62-0021
                  Brand Family Novabiochem®
                  Alternate Names
                  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole
                  Background InformationThis versatile reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis [1-3]. In recent years, it has been increasingly used for the esterification of Fmoc-amino acids onto solid phase synthesis supports [4-12]. It has proved particularly effective in difficult cases involving unreactive linkers [8, 9] or enantiomerization prone amino acids [7]. In an investigation [6] into ester formation, in which the alcohol or carboxylic acid component was immobilized on a solid support, MSNT was found to give the best results of all the reagents tested (DCC, DCC/HOBt, DCC/DMAP, Ph3P/DEAD).

                  The product number for this product was previously 01-62-0021.

                  To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
                  References
                  Product Information
                  CAS number74257-00-4
                  Hill FormulaC₁₁H₁₂N₄O₄S
                  Molar Mass296.31 g/mol
                  HS Code2935 00 90
                  Structure formula Image
                  Applications
                  ApplicationMSNT Novabiochem®. CAS 74257-00-4, molar mass 296.31 g/mol.
                  Biological Information
                  Physicochemical Information
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 3 highly water endangering
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at -15°C to -25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Colour (visual)white to slight yellow to beige
                  Appearance of substance (visual)powder
                  Identity (IR)passes test
                  Assay (HPLC, area%)≥ 95.0 % (a/a)

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  8510110001 Glas bottle pre packedPDF Specification Document
                  8510110005 Plastic bottlePDF Specification Document
                  8510110025 Plastic bottlePDF Specification Document

                  Brochure

                  Title
                  Novabiochem Coupling Reagent Flyer 2010
                  Novabiochem Innovations 03/10

                  Citations

                  Title
                  • [1] C. B. Reese, et al. (1978) Tetrahedron Lett., 19, 2727.
                  • [2] N. Balgobin, et al. (1981) Tetrahedron Lett., 22, 1915.
                  • [3] W. Bannwarth (1987) Chimia, 41, 302.
                  • [4] R. Frank, et al. (1988) Tetrahedron, 44, 6031.
                  • [5] B. Blankemeyer-Menge, et al. (1990) Tetrahedron Lett., 31, 1701.
                  • [6] J. Nielsen (1996) Tetrahedron Lett., 37, 8439.
                  • [7] E. Harth-Fritschy & D. Cantacuzène (1997) J. Peptide Res., 50, 415.
                  • [8] M. Renil, et al. (1998) J. Peptide Sci., 4, 195.
                  • [9] M. Meldal, et al. (1998) J. Peptide Sci., 4, 83.
                  • [10] A. Graven, et al. (2000) J. Chem. Soc., Perkin Trans. 1, 955.
                  • [11] K. S. Kumar, et al. (2001) J. Peptide Res., 57, 140.
                  • [12] H. Emtenäs, et al. (2002) J. Comb. Chem., 4, 630.

                  Reach Use

                  Title
                  Reach Use