MAB388-100UG Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1

MAB388-100UG
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ma IHC, IH(P), WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB388-100UG
      ReplacesMAB388
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1
      Alternate Names
      • PLP
      References
      Product Information
      FormatPurified
      Control
      • Brain
      PresentationPurified mouse immunoglobulin in PBS, pH 7.2 containing 0.09% sodium azide.
      Applications
      ApplicationDetect Myelin Proteolipid Protein using this Anti-Myelin Proteolipid Protein Antibody, C-terminus, clone PLPC1 validated for use in IH, IH(P) & WB.
      Key Applications
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesWestern Blotting: detects a 23-25kDa protein and DM20 a 20kDa protein; PLP can aggregate causing HMW bands to sometimes appear in certain preparations.

      Immunocytochemistry: 4% PFA fixed cells, 5-10 minutes room temperature. Use 0.1% triton in block only to allow antibody access to C-terminal epitope.

      Immunohistology on fresh frozen sections or 4% PFA fixed, frozen tissues. Epitope is internal, use 0.1-0.2% triton X-100 in the blocking step for permeabilization.

      Immunohistochemistry in paraffin: works best with lightly fixed tissues, or Bouin's fixed material, although there are reports of traditional formalin fixation also working with antigen recovery. {Mathis, et al 2003}.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMyelin proteolipid protein, synthetic peptide CGRGTKF corresponding to the C-terminal peptide.
      EpitopeC-terminus
      ClonePLPC1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with myelin proteolipid protein in many mammalian species. Shows cross-reactivity to DM20.
      IsotypeIgG2a
      Species Reactivity
      • Mammals
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
      Gene Symbol
      • PLP
      • PMD
      • MMP
      • SPG2
      • PLP/DM20
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
      SIZE: 277 amino acids; 30,077 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      PTM: Lipoprotein, Palmitate
      DISEASE:Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia.
      SIMILARITY: Belongs to the myelin proteolipid protein family.
      Molecular Weight23-25 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Myelin Proteolipid Protein Antibody, CT, clone PLPC1 Certificados de análisis

      CargoNúmero de lote
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) MONOCLONAL ANTIBODY - 21611002161100
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) MONOCLONAL ANTIBODY - 23435572343557
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) MONOCLONAL ANTIBODY - 23825902382590
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) MONOCLONAL ANTIBODY - 24531752453175
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) - 32170683217068
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) - 32887143288714
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) -25063232506323
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) -25939212593921
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) -26054522605452
      MOUSE ANTI-MYELIN PROTEOLIPID PROTEIN (PLP) -26891582689158

      Referencias bibliográficas

      Visión general referenciasAplicación EspeciePub Med ID
      Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann-Pick disease type A.
      Buccinnà, Barbara, et al.
      J. Neurochem., 109: 105-15 (2009)  2009

      Mostrar resumen
      19187445 19187445
      Guidance of glial precursor cell migration by secreted cues in the developing optic nerve.
      Sugimoto, Y, et al.
      Development, 128: 3321-30 (2001)  2001

      Mostrar resumen
      ImmunocytochemistryRat11546748 11546748
      Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition.
      Cheng, C M, et al.
      J. Neurosci., 18: 5673-81 (1998)  1998

      9671658 9671658