324694 Emodin - CAS 518-82-1 - Calbiochem

324694
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₅H₁₀O₅ 518-82-1

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1324694-50MG
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          Frasco de vidrio 50 mg
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          Description
          OverviewA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 µM). Also suppresses HER2/neu tyrosine kinase activity in HER2/neu overexpressing breast cancer cells.
          Catalogue Number324694
          Brand Family Calbiochem®
          Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
          References
          ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
          Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
          Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
          Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
          Product Information
          CAS number518-82-1
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₁₅H₁₀O₅
          Chemical formulaC₁₅H₁₀O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp56lck tyrosine kinase
          Primary Target IC<sub>50</sub>18.5 µM against p56lck tyrosine kinase
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCB7920600
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          324694

          Referencias bibliográficas

          Visión general referencias
          Pickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
          Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
          Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
          Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms6-Methyl-1,3,8-trihydroxyanthraquinone
          DescriptionA cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.
          FormOrange solid
          CAS number518-82-1
          RTECSCB7920600
          Chemical formulaC₁₅H₁₀O₅
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (1 mg/ml), Ethanol or Aqueous alkali
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.
          Toxicity Standard Handling
          Merck USA index14, 3561
          ReferencesPickhardt, M., et al. 2004. J. Biol. Chem. 280, 3628.
          Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
          Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
          Jayasuriya, H., et al. 1992. J. Nat. Prod. 55, 696.